This study aims to compare the efficacy of nasal provocation test with Lysine-Acetylsalicylate in patients with history of NSAIDs hypersensitivity between mucocutaneous symptoms and respiratory symptoms and laboratory outcomes.

Inclusion Criteria:

• Patients with history of ASA/NSAIDs hypersensitivity with mucocutaneous symptoms and/or respiratory symptoms

Exclusion Criteria:

• Patients who cannot discontinue drugs before the test as follow

  • Nasal corticosteroids/Oral corticosteroids/Leukotriene modifiers for 1 week
  • Short-acting antihistamines for 3 days
  • Nasal a-mimetics/Oral a-mimetics/Local cromones for 24 hours

• Contraindicated for nasal provocation test: pregnant, exacerbation of allergic rhinitis/asthma, having upper respiratory tract infection within 2 weeks prior to the test, having nose surgery within 8 weeks prior to the test, having severe systemic disease(s)

• Having factors interfere nasal provocation test with Lysine-ASA such as massive nasal polyp, nasal septal perforation, total nasal obstruction at least 1 nostril