The study is an investigator-run, open-label Phase 1 safety study of autologous mesenchymal stem cell transplantation, involving approximately 24 ambulatory participants with relapsing forms of MS (approximately equal numbers with relapsing-remitting and secondary progressive/ progressive relapsing MS) and evidence of involvement of the anterior afferent visual system.

Inclusion Criteria:

• Age 18 to 55, inclusive.
• Diagnosis of MS
• Relapsing form of MS (relapsing-remitting, secondary progressive, or progressive-relapsing course).
• EDSS score 3.0-6.5, inclusive. (Must be able to walk)
• Active disease during prior 24 months.
• Documented evidence of involvement of the anterior afferent visual system: previous optic neuritis, optic atrophy or an afferent pupillary defect on exam, RNFL thickness on OCT \