Single and Multiple Ascending Dose Safety Study of XPF-001 in Healthy Volunteers

Phase 1, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of XPF-001 and to Investigate the Effect of Food on the Pharmacokinetics of a Single Dose of XPF-001 in Healthy Subjects

The purpose of this study is to assess the safety, tolerability and pharmacokinetics of single and multiple doses of XPF-001 in healthy volunteers.

The effect of food on the pharmacokinetics of XPF-001 will also be studied.

Inclusion Criteria:

• Healthy subjects (Females of non-childbearing potential) with normal or clinically insignificant laboratory results, ECGs and physical examinations.

Exclusion Criteria:

• Subjects with a presence or history of any clinically significant disease.
• Subjects who have participated in and investigational drug trial within 60 days of admission.
• Subjects who have used tobacco or nictoine products in the 1 month prior to admission
• Females who are pregnant or breastfeeding