The purpose of this study is to assess the safety, tolerability and pharmacokinetics of single and multiple doses of XPF-001 in healthy volunteers.

The effect of food on the pharmacokinetics of XPF-001 will also be studied.

Inclusion Criteria:

• Healthy subjects (Females of non-childbearing potential) with normal or clinically insignificant laboratory results, ECGs and physical examinations.

Exclusion Criteria:

• Subjects with a presence or history of any clinically significant disease.
• Subjects who have participated in and investigational drug trial within 60 days of admission.
• Subjects who have used tobacco or nictoine products in the 1 month prior to admission
• Females who are pregnant or breastfeeding