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This is an explorative study and the scientific question to be investigated in this study is if AZD0837 and/or its metabolites AR-H069927XX and AR-H067637XX and other unknown metabolites are excreted into the bile.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD0837 | Drug | Oral solution, dosing through the Loc-I-Gut catheter, single dose |
| Measure | Description | Time Frame |
|---|---|---|
| The amounts of total radioactivity excreted in bile. Metabolic profile of AZD0837 excreted in bile and identification of previously unknown metabolites and the amounts of AZD0837, AR-H069927XX and AR-H067637XX in bile. | Frequent sampling through a Loc-I-Gut catheter for up to 3 hours post dose. |
| Measure | Description | Time Frame |
|---|---|---|
| PK variables of AZD0837, AR-H069927XX, and AR-H067637XX. | Frequent sampling during 24 hours. | |
| Adverse events, physical examination, safety laboratory variables, blood pressure, pulse and electrocardiography. | Some of the safety variables will be followed at each visit, some less frequent. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lars Knutson, MD, PhD | Inst för Kirurgiska VetenskaperUppsala Universitet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Uppsala | Sweden |
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| ID | Term |
|---|---|
| C551586 | AZD 0837 |
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