Regulation of Hepatic Insulin Extraction

Regulation of Hepatic Insulin Extraction:Alterations of Insulin Secretion in Subjects With Genetic Variants That Determine Risk for Non-Insulin Dependant Diabetes Mellitus

• This study is in the area of Type 2 diabetes and genetics
• Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate
• This study is searching for genes that may affect the body's processing/digestion of glucose/sugar

This study is looking at the genetic influences of type 2 diabetes. It also is investigating the various gastric hormones including but not limited to: insulin, C-peptide, GIP, GLP, & Xenin.

Inclusion Criteria:

• ages 18-65
• non-diabetic
• diabetes controlled with diet or with pills
• no family history of diabetes
• family history of type 2 diabetes
• personal history of gestational diabetes

Exclusion Criteria:

• < 18 or > 65 years of age
• medications that affect glucose (sugar) levels
• kidney disease
• liver disease
• heart/cardiovascular disease