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| Name | Class |
|---|---|
| University of Leipzig | OTHER |
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The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.
Groups of patients with different immune competencies will be examined. The impact of HIV infection on immune response will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIV infected individuals, HIV controllers | CD4+ T cell count > 350/µl, HIV load < 1000 copies/ml | ||
| HIV infected individuals, early progressors | CD4+ T cell count > 350/µl, HIV load > 1000 copies/ml | ||
| HIV infected individuals, late progressors | CD4+ T cell count < 200/µl | ||
| HIV infected individuals, late progressors with therapy | CD4+ T cell count < 200/µl, under ART | ||
| Healthy individuals | Uninfected |
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| Measure | Description | Time Frame |
|---|---|---|
| Antigen specific B-cell responses | 18 months |
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Inclusion Criteria:
Exclusion Criteria:
- none
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HIV patients and controls attending specialised clinics, Germany
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| Name | Affiliation | Role |
|---|---|---|
| Christian Jassoy, MD | Universität Leipzig | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universität Leipzig | Leipzig | Saxony | 04103 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19962720 | Result | Bussmann BM, Reiche S, Bieniek B, Krznaric I, Ackermann F, Jassoy C. Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV. Virology. 2010 Feb 5;397(1):7-13. doi: 10.1016/j.virol.2009.11.003. Epub 2009 Dec 4. | |
| 21860350 | Result | Kunz K, Reiche S, Dwai Y, Cordes C, Krznaric I, Bussmann BM, Jassoy C. A broad spectrum of functional HIV-specific memory B cells in the blood of infected individuals with high CD4+ T-cell counts. J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):e56-8. doi: 10.1097/QAI.0b013e31821dd9d1. No abstract available. |
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| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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peripheral blood
| 24566009 | Result | Reiche S, Nestler C, Sieg M, Schulz K, Cordes C, Krznaric I, Jassoy C. Hepatitis C virus (HCV)-specific memory B-cell responses in transiently and chronically infected HIV positive individuals. J Clin Virol. 2014 Apr;59(4):218-22. doi: 10.1016/j.jcv.2014.01.023. Epub 2014 Feb 4. |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |