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Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retinitis pigmentosa | Active Comparator |
| |
| Macula off | Active Comparator | condition after treatment of retinal detachment |
|
| Primary open angle Glaucoma | Active Comparator |
| |
| Hereditary Macular Degeneration | Active Comparator |
| |
| Treated Retina detachment | Active Comparator |
| |
| Retinal Artery Occlusion | Active Comparator |
| |
| Retinal Vein Occlusion | Active Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcorneal Electrical Stimulation | Device | Neurostimulator drives Dawson-Trick-Litzkow electrode attached to patient eye. Different modi are used to stimulate patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| enhanced field of vision, enhanced visual acuity, lower threshold for electrical evoked phosphenes | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Florian Gekeler, MD, Prof | University-Eye-Hospital, Centre for Ophthalmology, D-72076 Tübingen, Germany | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21467183 | Result | Schatz A, Rock T, Naycheva L, Willmann G, Wilhelm B, Peters T, Bartz-Schmidt KU, Zrenner E, Messias A, Gekeler F. Transcorneal electrical stimulation for patients with retinitis pigmentosa: a prospective, randomized, sham-controlled exploratory study. Invest Ophthalmol Vis Sci. 2011 Jun 23;52(7):4485-96. doi: 10.1167/iovs.10-6932. | |
| 23049087 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 8, 2013 | |
| Reset | Dec 30, 2013 | |
| Release | Oct 14, 2015 |
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|
| Non-Arteriitic-Anterior-Ischemic Optic-Neuropathy | Active Comparator |
|
| Hereditary autosomal dominant Optic atrophy | Active Comparator |
|
| dry Age-related Macular Degeneration | Active Comparator |
|
| Ischemic Macula edema | Active Comparator |
|
| Non-stimulated | Sham Comparator |
|
| DTL-electrode attached without energy | Device | DTL-electrode attached to patient eye receives no energy from neurostimulator. Treatment times remain the same as used for each treatment arm. |
|
| Naycheva L, Schatz A, Rock T, Willmann G, Messias A, Bartz-Schmidt KU, Zrenner E, Gekeler F. Phosphene thresholds elicited by transcorneal electrical stimulation in healthy subjects and patients with retinal diseases. Invest Ophthalmol Vis Sci. 2012 Nov 1;53(12):7440-8. doi: 10.1167/iovs.12-9612. |
| Reset | Nov 12, 2015 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 8, 2013 | Dec 30, 2013 | |||
| Oct 14, 2015 | Nov 12, 2015 |
| ID | Term |
|---|---|
| D012174 | Retinitis Pigmentosa |
| D005902 | Glaucoma, Open-Angle |
| D015356 | Retinal Artery Occlusion |
| D012170 | Retinal Vein Occlusion |
| D029241 | Optic Atrophy, Autosomal Dominant |
| ID | Term |
|---|---|
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D058499 | Retinal Dystrophies |
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020246 | Venous Thrombosis |
| D013927 | Thrombosis |
| D016769 | Embolism and Thrombosis |
| D015418 | Optic Atrophies, Hereditary |
| D009896 | Optic Atrophy |
| D009901 | Optic Nerve Diseases |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D028361 | Mitochondrial Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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