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Aim of the study is to detect the prevalence of chronic rhinosinusitis, pathogen colonization of the lower and upper airways and, in a sub-cohort the sense of smelling in patients with cystic fibrosis.
The sub-study on the sense of smelling in CF has been finalized in the meantime. Results were published in 2012:
Smell in cystic fibrosis. Lindig J, Steger C, Beiersdorf N, Michl R, Beck JF, Hummel T, Mainz JG. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):915-21. doi: 10.1007/s00405-012-2124-2. Epub 2012 Aug 14.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CF patients of all age groups | Longitudinal prospective assessment of upper and lower airway colonization in all patients attended in the Jena University CF centre |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nasal lavage and sputum collection | Other | non-invasive longitudinal assessment of pathogen colonization in both airway levels |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dynamics in CF upper and lower airway colonization with pathogens | longitudinal non-invasive sampling of upper and lower airways in CF | 10 years |
| Assessment of ability to smell in CF patients | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| pulmonary function / BMI | 10 years |
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Inclusion Criteria:
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patients of the CF outpatients clinic and hospitalized CF patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jochen Mainz, MD | Contact | +49 3641 938425 | Jochen.Mainz@med.uni-jena.de |
| Name | Affiliation | Role |
|---|---|---|
| Jochen Mainz, MD | University of Jena - CF Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Jena - CF-Center | Recruiting | Jena | 07740 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22890694 | Background | Lindig J, Steger C, Beiersdorf N, Michl R, Beck JF, Hummel T, Mainz JG. Smell in cystic fibrosis. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):915-21. doi: 10.1007/s00405-012-2124-2. Epub 2012 Aug 14. | |
| 22045752 | Background | Mainz JG, Michl R, Pfister W, Beck JF. Cystic fibrosis upper airways primary colonization with Pseudomonas aeruginosa: eradicated by sinonasal antibiotic inhalation. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1089-90. doi: 10.1164/ajrccm.184.9.1089. No abstract available. |
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| ID | Term |
|---|---|
| D012852 | Sinusitis |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010254 | Paranasal Sinus Diseases |
| D009668 | Nose Diseases |
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| ID | Term |
|---|---|
| D055556 | Nasal Lavage |
| ID | Term |
|---|---|
| D007507 | Therapeutic Irrigation |
| D008919 | Investigative Techniques |
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| 22133899 | Background | Mainz JG, Hentschel J, Schien C, Cramer N, Pfister W, Beck JF, Tummler B. Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation. J Cyst Fibros. 2012 Mar;11(2):158-61. doi: 10.1016/j.jcf.2011.10.009. Epub 2011 Nov 30. |
| 19282318 | Background | Mainz JG, Naehrlich L, Schien M, Kading M, Schiller I, Mayr S, Schneider G, Wiedemann B, Wiehlmann L, Cramer N, Pfister W, Kahl BC, Beck JF, Tummler B. Concordant genotype of upper and lower airways P aeruginosa and S aureus isolates in cystic fibrosis. Thorax. 2009 Jun;64(6):535-40. doi: 10.1136/thx.2008.104711. Epub 2009 Mar 11. |
| D012140 |
| Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |