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The purpose of this investigation, in which pilocarpine was given in repeated doses, was to evaluate: Part I - the effects of different concentrations of pilocarpine hydrochloride on intraocular pressure. Part II -the effects on intraocular pressure of glaucomatous patients to pilocarpine 2% when given once, twice and four daily. In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.
In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pilocarpine Concentration | Experimental | Varying concentration 0.5 to 8% - 22 patients were examined regarding: visual acuity, iris color, pupil size, chamber angle, C/D ratio, visual field (VF), coefficient of aqueous outflow and Goldmann tonometry. After a one month washout period, pilocarpine was used 4 times daily, in concentrations from 0.5 to 8%. The amount of IOP change was compared with various clinical findings |
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| Pilocarpine Frequency | Experimental | Varying frequency, once to four times daily - 15 patients were included in a crossover study: IOP was checked daily for 3 days and for 9 hours on fourth day. Pilocarpine was started on day 5 once daily OD and BID OS; on day 9 once daily OD and QID OS; on day 12 QID OD and once daily OS; on day 16 once daily OD and QID OS; and on day 19 QID OD and once daily OS. No medications were used on days 23-25. IOP was measured on days 4, 8, 11, 15, 18, 22 and 25. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pilocarpine Concentration | Drug | Varying concentration 0.5 to 8% |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Intraocular Pressure | 25 days |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| George L Spaeth, MD | Wills Eye Glaucoma Service | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wills Eye Glaucoma Service | Philadelphia | Pennsylvania | 19107 | United States |
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| Pilocarpine Frequency |
| Drug |
1 to 4 times daily |
|