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The incretin effect is markedly reduced in patients with type 2 diabetes. Data support the notion that this deficiency is a consequence of the diabetic state. However, the impact of insulin resistance on the incretin effect in obese individuals who uphold a normal glucose tolerance (NGT) despite their insulin resistant state remains to be elucidated. The primary aim of the present study is to evaluate the separate impact of one of the cornerstones of type 2 diabetic pathophysiology, namely insulin resistance, on the incretin effect in lean and obese patients with type 2 diabetes and in two matched normal-glucose tolerant groups of healthy control subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese patients with type 2 diabetes | Patients with type 2 diabetes and BMI>33 |
| |
| Obese subjects with normal glucose tolerance | Subjects with normal glucose tolerance and BMI>33 |
| |
| Lean subjects with type 2 diabetes | Patients with type 2 diabetes and BM<25 |
| |
| Lean subjects with normal glucose tolerance | Subjects with normal glucose tolerance and BM<25 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral glucose tolerance test (OGTT) | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incretin effect | 2 days |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin resistance | 2 days |
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Inclusion Criteria:
Exclusion Criteria:
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Lean and obese patients with type 2 diabetes; and matched healthy control subjects.
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| Name | Affiliation | Role |
|---|---|---|
| Tina Vilsbøll, MD DMSc | Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gentofte Hospital, University of Copenhagen | Hellerup | Copenhagen | 2900 | Denmark |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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Blood samples
| Isoglycemic intravenous glucose infusion | Other |
|
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |