The purpose of this study is to evaluate the relative bioavailability of the test formulation of mesalamine suspension rectal enema with the reference formulation in healthy, adult subjects.

Inclusion Criteria:

• healthy men or women, 18 to 55 years of age
• weight within +/- 25% for height and weight for body frame
• willing to participate and sign a copy of the informed consent form

Exclusion Criteria:

• recent history of drug or alcohol addiction or abuse
• pregnant or lactating women
• history of allergic response to mesalamine
• evidence of a clinically significant disorder or whose laboratory results were deemed to be clinically significant
• receipt of any drugs as part of a research study within 28 days prior to study dosing