This study is to determine if the BridgePoint Medical System (CrossBoss Catheter, Stingray Catheter, Entera Guidewire) can facilitate safe and effective placement of a guidewire in the true lumen of coronary vessels distal to a chronic total occlusion (CTO).

The hypothesis is that the BridgePoint Medical System can do this without an increase in major complications.

Inclusion Criteria:

• Suitable for coronary intervention
• de novo or restenotic CTO at least 3 months old, in proximal or mid coronary artery segment, 3.0-5.0 mm in diameter
• Mild/moderate proximal vessel tortuosity
• Mild/moderate lesion angulation
• Mild/moderate calcification
• Satisfactory distal vessel visualization
• Mild/moderate side branch interference
• 19 years old
• BMI<40
• LVEF>20%
• Signed informed consent

Exclusion Criteria:

• Extensive dissection from guidewire manipulation
• SVG or in-stent CTO
• Aorto-ostial CTO
• Unable to take aspirin, Clopidogrel, or Ticlopidine
• Thrombus/vessel filling defects
• Severe cerebrovascular disease/stroke within 1 month
• Intervention within 2 weeks
• Renal insufficiency
• GI bleeding
• Active infection
• Life expectancy <2 years
• Significant anemia
• Uncontrolled hypertension
• Severe electrolyte imbalance
• Anaphylaxis to contrast
• NYHA class IV
• Unstable angina requiring intervention
• MI within 2 weeks
• Uncontrolled diabetes
• Participating in another protocol
• Unwilling/unable to comply with protocol
• Angina/ischemia caused by target vessel