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Young women with breast cancer have an increased breast tissue density and conventional imaging tests such as mammography and breast ultrasound are less sensitive and specific for detecting breast cancer than in older breast cancer patients. Breast MRI is an emerging tool that has been proven to improve the ability to identify breast cancers by determining the extent of disease and also detect multifocal, multicentric and bilateral breast cancers. To date, the role of pre-operative breast MRI is not clearly defined. The investigators are proposing a study to evaluate the impact of preoperative breast MRI on surgical decision-making in breast cancer patients <= 50 years. This may lead to improved characterization of breast cancers in these younger patients that may ultimately result in lower local recurrence rates in the future. The additional information attained through the breast MRI may also guide the use of radiation, chemotherapy and/or hormonal therapy in these patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pre-operative bilateral breast MRI | Procedure | After the standard mammogram and ultrasound testing, the surgeon is asked which surgical procedure they feel is appropriate for the patient. A bilateral breast MRI is then performed prior to surgery. The surgeon is again asked which surgery they feel is appropriate based on the new information provided by the MRI. The study is trying to see if this pre-operative breast MRI helps define the tumour leading to a better first surgical decision. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Does pre-operative magnetic resonance imaging (MRI) effect surgical management in young women with breast cancer | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients requiring a second surgery due to positive tumour margins. | 3 months | |
| Incidence of multifocal or multicentric or bilateral breast cancer found on MRI | After surgery | |
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shelley A Chambers, MA | Contact | 905-387-9711 | 64510 | shelley.chambers@jcc.hhsc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Nicole Hodgson, MD | Juravinski Cancer Centre | Principal Investigator |
| Som D Mukherjee, MD | Juravinski Cancer Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Josephs' Healthcare | Recruiting | Hamilton | Ontario | L8N 4A6 | Canada |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| The correlation between MRI tumour size and the pathologic tumour size after surgery. |
| 3 months |
| Juravinski Cancer Centre | Recruiting | Hamilton | Ontario | L8V 5C2 | Canada |
|
| D017437 |
| Skin and Connective Tissue Diseases |