PI left JHU

The goal of this present proposal is to examine the efficacy of GLP-1 administered to control blood glucose in critically ill patients.

All patients whom on admission to the ICU (surgical, burn, & cardiac) who are expected to receive intensive insulin therapy for at least 72 hours are eligible to be enrolled. Once enrolled, the patients will be randomized to one of two groups: the experimental (intravenous GLP-1 infusion for 72 hours) or control groups (intravenous 0.9% sodium chloride (NaCl) infusion for 72 hours) in a double masked fashion. While enrolled, all patients will receive standard-of-care insulin therapy. Both groups will be maintained on the standard ICU specific protocol for glucose control.

Inclusion Criteria:

• Men and women age > 21 to 75 years of age.
• All subjects who meet ICU specific criteria for inclusion in their glucose protocol and placed on insulin infusion protocol as standard of care.
• Able to obtain patient or proxy consent.

Exclusion Criteria:

• Current diagnosis of malignancy.
• Type 1 diabetes.
• Inability to obtain informed consent.
• On any Phase 1 trial.

The PI left the institution and this study was terminated due to noncompliance with our Institutional Review Board. Adverse event data, if collected, is unknown since no data are available.