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Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.
We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.
Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | Ketamine pre and per operative, and morphine postoperative |
|
| B | Active Comparator | NaCl pre and per operative, and morphine postoperative |
|
| C | Experimental | Ketamine and morphine postoperative |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketamine-Morphine | Drug | Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Morphine consumption in PACU and in hospitalisation room | at 24 and 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Visual Analogic Score of pain | in Recovery Room, at 24 and 48 hours, in the ward | |
| Postoperative Measure of mechanical hyperalgesia by Von Frey filament device | 24 and 48 hours in the ward |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe SITBON, MD | Assistance Publique - Hôpitaux de Paris Hôpital Bicêtre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'anesthesie-reanimation - Hôpital Bicêtre | Le Kremlin-Bicêtre | 94270 | France |
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| ID | Term |
|---|---|
| D006930 | Hyperalgesia |
| ID | Term |
|---|---|
| D020886 | Somatosensory Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D009020 | Morphine |
| ID | Term |
|---|---|
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
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| Morphine | Drug | Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA) |
|
| Postoperative PCA of Ketamine and morphine | Drug | Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA) |
|
|
| Postoperative measure Ketamine and Nor-Ketamine blood levels | at 24 and 48 hours in the ward |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006571 |
| Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |