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| ID | Type | Description | Link |
|---|---|---|---|
| NJFY0811-MZ02 |
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Uterine curettage is usually performed under the anesthesia of propofol-fentanyl or para-cervical block,of which generally has significant incidence of respiratory depression which increases the demand on intraoperative monitoring, or has unavoidable insufficient blockade which results in intraoperative suffering of pain. Butorphanol is an analgesic with combined effects on mu and kappa opioid receptors leading to a role as analgesia and sedation. The investigators hypothesized that combined propofol with butorphanol during uterine curettage would produce optimal effectiveness of these two drugs by adding sedative and analgesic effects together. In addition, it would decrease the intraoperative consumption of propofol without increase the incidence of side effects. Furthermore, such combination would alleviate postoperative pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Propofol-fentanyl combined anesthesia |
|
| 2 | Experimental | Propofol-butorphanol combined anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fentanyl Citrate | Drug | Combined anesthesia with propofol (2-2.5mg/kg) and fentanyl (5 μg) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative awareness | During the whole process of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Bispectral Index (BIS) value | During the whole process of anesthesia | |
| Anesthetic consumptions | From the start of operation to the end of surgical procedures | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| XiaoFeng Shen, MD | Nanjing Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing Maternal and Child Health Care Hospital | Nanjing | Jiangsu | 210004 | China |
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| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D002077 | Butorphanol |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009019 | Morphinans |
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| Butorphanol Tartrate | Drug | Combined anesthesia with propofol (2-2.5 mg/kg) and butorphanol (1mg) |
|
|
| Postoperative pain |
| Since the end of the operation to 48 h follow-up. |
| Postoperative bleeding | Since the end of operation to 48 h follow-up |
| D053610 |
| Opiate Alkaloids |
| D000470 | Alkaloids |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |