Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery

Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery

The primary objective of this study is to (1) determine whether local injection of lidocaine used during Mohs surgery will elevate serum lidocaine concentrations to a level that could cause systemic symptoms and (2) determine whether sustained high levels of serum lidocaine occur after intralesional anesthesia on the face and neck. This study is a cross-sectional study of 10 subjects with basal cell carcinoma or squamous cell carcinoma of the face or neck requiring Mohs micrographic surgery. The study will consist of a brief questionnaire and blood draws during their Moh's surgical procedure.

Inclusion Criteria

• Age: 18-75
• Basal cell carcinoma or squamous cell carcinoma of the head or neck
• Subjects are in good health
• Subjects that have the willingness and the ability to understand and provide informed consent for the use of their blood and communicate with the investigator

Exclusion Criteria

• Lidocaine sensitivity
• Bleeding disorder
• Pregnancy
• Medical conditions which would impair hepatic blood flow: congestive heart failure, liver dysfunction, peripheral vascular disease.
• Subjects who are unable to understand the protocol or to give informed consent
• Subjects with mental illness