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End of study time and budget permission
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| Name | Class |
|---|---|
| Thai health promotion foundation. | UNKNOWN |
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The purpose of this study is to determine whether adding load to slow controlled breathing training could enhance blood pressure lowering in patients with essential hypertension.
Hypertension (HT) is one of the major risk of cardiovascular diseases and cost of pharmacological treatment is a very high. Lifestyle modification is the first trial in stage 1 hypertension before commencing pharmacological treatment and a co-treatment with drug in hypertensive patient. Slow paced breathing training and physical training has been shown to reduce both systolic and diastolic blood pressure in HT. Moreover loaded breathing was reported to be able to decrease blood pressure in healthy. Loaded slow breathing training may enhance the antihypertensive effect of slow paced breathing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | The patients in this control group do not conduct any breathing training. | |
| ULB | Experimental | The patients conduct controlled slow breathing training using the WPTB device without inspiratory resistance. |
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| LB | Experimental | The patients breath in against resistance using WPTB device. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ULB , LB | Device | ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Home blood pressure | Pre- and post - 8 weeks of intervention at rest |
| Measure | Description | Time Frame |
|---|---|---|
| Office blood pressure | Pre- and post- 8 weeks of intervention at rest | |
| Exercising blood pressure | Blood pressure during exercise at pre- and post-8 weeks of intervention | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chulee U Jones, Ph.D. | Department of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University. | Study Chair |
| Benjarat Sangthong, M.Sc. | Faculty of Physical Therapy, Rungsit University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiopulmonary Physical Therapy Research Room, Faculty of Asociated Medical Sciences, Khon Kaen University. | Khon Kaen | 40002 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | - Seals DR, Suwarno NO, Joyner MJ et al.Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circulation Research 72(2): 440-454,1993. - Rosenthal T, Alter A, Peleg E, Gavish B. Device-guided breathing exercises reduce blood pressure: ambulatory and home measurements. Am J Hypertens 14(1):74-76,2001. - Viskoper R, Shapira I, Priluck R et al.Nonpharmacologic treatment of resistant hypertensive by device-guided slow breathing exercises. Am J Hypertens 16(6): 484-487,2003. - Grossman E, Grossman A, Schein MH et al.Breathing-control lowers blood pressure. J Hum Hypertens 15(4): 263-269,2001. - Viskoper R, Shapira I, Priluck R et al.Nonpharmacologic treatment of resistant hypertensive by device-guided slow breathing exercises. Am J Hypertens 16(6):484-487,2003 - Meles E, Giannattasio C, Failla M. et al.Non-pharmacologic treatment of hypertension by respiratory exercise in the home setting. Am J Hypertens 17(4):370-374,2004. |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Heart rate variability |
| Heart rate variability at pre-and post- 8 weeks of intervention |