A Study to Assess the Safety and Tolerability of ASP1941 in Adults With Type 2 Diabetes Mellitus.

A Phase 2a, Randomized, Double-Blind, Placebo Controlled, Multiple Dose Study to Assess the Safety and Tolerability of ASP1941 in Adult Subjects With Type 2 Diabetes Mellitus

This study is intended to assess safety and tolerability of ASP1941 compared to placebo in adult subjects with type 2 diabetes mellitus

Trial includes a two week washout period before entering the treatment period for subjects on oral anti-diabetic medication.

Inclusion Criteria:

• Established diagnosis of type 2 diabetes mellitus
• HbA1c value between 7.0 and 10.0%
• Body mass index between 20 and 45 kg/m2

Exclusion Criteria:

• Established diagnosis of type 1 diabetes mellitus
• Serum creatinine > upper limit of normal range
• Proteinuria (microalbumin/creatinine ratio > 300 mg/g)
• Urinary tract infection
• Severe uncontrolled Hypertension
• Significant renal, hepatic or cardiovascular disease
• HIV Positive
• History of drug or alcohol abuse/dependency