Early Diabetes Resolution After Weight Loss Surgery

Hormonal and Inflammatory Parameters Affecting Early Diabetes Resolution Following Weight Loss Surgery

The primary objective is to compare inflammatory, hormonal, and metabolic changes in the very short term after various bariatric surgical procedures (Roux-en Y Gastric Bypass, Vertical Sleeve Gastrectomy, and Adjustable Gastric Banding)and other abdominal surgeries, as well as to compare these changes to diet-induced changes in the same population.

Inclusion Criteria for surgery groups:

• BMI of 30 kg/m2 or higher
• Ages 18-65
• History of impaired glucose tolerance or T2DM

Inclusion Criteria for normal weight group:

• BMI of 30 kg/m2 or lower
• Ages 18-65

Exclusion Criteria:

• Development of an intercurrent infection
• Prior gastric, duodenal, proximal jejunal surgery or pancreas resection
• Current use of thiazolidinediones
• Current use of dipeptidyl peptidase-IV inhibitors (e.g., sitagliptin) or glucagon-like peptide-1 analogs (e.g., exenatide)
• Any condition felt by the PI or co-investigators to interfere with ability to complete the study