To Evaluate the Hormonal Response to Low Blood Sugar After a Single Oral Dose of AZD1656 Suspension

A Randomized, Open, Two-Way Cross-Over, Single-Centre, Phase I Study to Assess the Counter Regulatory Response During Hypoglycaemia in Healthy Male Volunteers After a Single Oral Dose of AZD1656 Suspension in Comparison With Insulin Infusion

To evaluate the hormonal response to low blood sugar after a single oral dose of AZD1656 suspension.

Inclusion Criteria:

• Healthy male volunteers.
• Clinically normal physical findings (incl. Electrocardiogram (ECG)) and laboratory values as judged by the investigator.
• Have a body mass index (BMI) ≥19 and ≤30

Exclusion Criteria:

• Clinically significant illness or clinically relevant trauma, as judged by the investigator, within 2 weeks before the first administration of the investigational product
• Intake of any prescribed medicine and OTC drugs (including herbals, vitamins and minerals), except for occasional paracetamol or nasal spray for nasal congestion, within two weeks before the first administration of the investigational product.
• Daily use of nicotine containing substances.