A Safety Study of ARRY-371797 in Healthy Subjects

A Randomized, Double-Blind, Placebo-Controlled, Single Day And Multiple Day Ascending Dose Study To Evaluate The Safety And Pharmacokinetics Of Orally Administered ARRY-371797 In Healthy Volunteers

This is a Phase 1 study, involving both 1-day and 8-day dosing periods, designed to test the safety of investigational study drug ARRY-371797 in healthy subjects. Approximately 48 healthy subjects from the US will be enrolled in this study.

Key Inclusion Criteria:

• Healthy male or female between the ages of 18 and 60 years.
• Females must be of nonchildbearing potential.
• Body weight > 50 kg (110 lbs) and < 113 kg (250 lbs).
• Additional criteria exist.

Key Exclusion Criteria:

• A positive test for drugs or alcohol.
• Use of prescription or nonprescription drugs, herbal or dietary supplements, vitamins, or grapefruit juice within 14 days prior to first dose of study drug.
• Additional criteria exist.