Very slow in enrolling participants

The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.

Inclusion Criteria:

• The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features.

  1. corneal epithelial defect with stromal infiltration
  2. reaction in anterior chamber
  3. positive for bacteria or fungus

• The patients have to receive subconjunctival antibiotic injection twice at least.

• The patients must be informed consent.

Exclusion Criteria:

• The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs.
• The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection.
• Unable to cooperate with the treatment.
• Pregnant women