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difficulty with recruitment
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Improvements in In-Vitro Fertilization (IVF) outcomes have largely been due to the generation of excess embryos allowing for multiple embryo transfer. Unfortunately this has also increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and mortality. The investigators believe that the concentration of nitric oxide metabolites measured in the culture medium from the first day of culture can identify the best quality embryos allowing us to transfer a limited number of embryos without compromising the optimum chance for pregnancy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Day 3 transfer | Active Comparator | Subjects in this arm will have two embryos transferred three days after fertilization. Embryos will be selected based on the concentration of nitric oxide metabolites in the culture medium. |
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| Day 5 transfer | Active Comparator | Subjects will have two embryos transferred on day 5 after fertilization with selection of embryos based on morphologic criteria. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transfer of embryos on day 3 or day 5 after fertilization. | Procedure | Subjects will be allocated at random to the two arms. Group 1 will have two embryos transferred on day 3 based on nitric oxide concentration. Group 2 will have two embryos transferred on day 5 based on morphologic criteria. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of subjects with viable pregnancy one month after embryo transfer | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of subjects with > 2 viable embryos one month after embryo transfer | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lisa A Kolp, M.D. | Johns Hopkins University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins Fertility Center | Lutherville | Maryland | 21093 | United States |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| Day 5 transfer | Procedure | Subjects will have embryo transfer on day 5 after fertilization. Selection of embryos to transfer will be based on morphologic criteria. |
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