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Patients who is scheduled elective PCI are randomized to pitavastatin 4mg daily or without pitavastatin for 5 -7days before the procedure. Creatine kinase-MB, troponin I, and myoglobin levels are measured at baseline and at 8 and 24 hours after the procedure(1st evaluation). After PCI, pitavastatin will be administered for additional 4 weeks(2nd evaluation).
Procedural ischemic myocardial injury remains the most frequent complication after coronary angioplasty. Recently it was reported that pretreatment with atorvastatin reduce the myocardial damage compared to placebo. Thus, we will evaluate the difference of pretreatment of pitavastatin compared to standard therapy on the reduction of myocardial damage in patient who is scheduled elective PCI for stable angina pectoris.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pitavastatin Group | Experimental |
| |
| Usual Care Group | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pitavastatin | Drug | 4mg daily for 5-7 days before Percutaneous Coronary Intervention(PCI) and 4mg daily for 28 days after PCI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients whose CK-MB > 2 times above UNL | First evaulation time (before PCI) |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients who show any increase of CK-MB, troponin I, and myoglobin above UNL | First evaluation time | |
| Mean peak values of CK-MB, troponin I and myoglobin after intervention | After PCI (<24hrs) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ki Bae Seung, Ph.D | Professor, Catholic University of Korea Kangnam St. Mary's Hospital located | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Catholic University of Korea Kangnam St. Mary's Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D060050 | Angina, Stable |
| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C108475 | pitavastatin |
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| Pitavastatin | Drug | 4mg daily for 28 days after PCI |
|
| Change of hs-CRP, wall motion score | Second evaluation time |
| Occurence of all major adverse cardiac events | Second evaluation time |
| D014652 |
| Vascular Diseases |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |