Diaphragmatic Function in Ventilated Patients

Ventilator-Induced Diaphragmatic Dysfunction (VIDD) in Critically Ill Patients

Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).

Inclusion Criteria:

• Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.·
• Duration of mechanical ventilation for at least 72h.·
• Subject itself or its next of kin has given written informed consent

Exclusion Criteria:

• Patient is less than 18 years or more than 85 years of age·
• The attending physician refuses to allow enrollment·
• The patient refuses informed consent
• Next of kin is unavailable or refuses informed consent·
• Pregnant or breast-feeding female.
• A pregnancy test will be performed in all female patients less than 60 years of age.·
• Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).·
• Presence or suspicion of prior diaphragm injury or chronic disease·
• Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection