Anesthesic Propofol and Remifentanil Requirements in Obese Patients

Intravenous Anesthesia in Obese Patients: Propofol and Remifentanil Requirements

Pharmacokinetic models for anesthetic agents are questionable. The objective of the study is to compare the propofol and remifentanil doses required to maintain the bispectral index in the range 40-60 in two groups of patients: obese patients and lean patients

Inclusion Criteria:

- Patients scheduled for a bariatric coelioscopic surgical procedure (obese patients) or for an upper abdominal laparoscopic procedure (lean patients)

Exclusion Criteria:

• age lower than 18 years,
• pregnant woman,
• presence of a central neurological disorder or a lesion cerebral, of a severe respiratory or hepatic insufficiency,
• allergy to propofol, or to soja or to peanuts, or to sufentanil, or to remifentanil, or to morphine, or to a muscle myorelaxant, or to an excipient,
• hypersensibility to sufentanil, or to remifentanil or to another derivate of fentanyl,
• allergy to latex,
• presence of a symptomatic gastroesophageal reflux,
• patients receiving a psychotropic treatment or a agonist-antagonist opiate,
• presence of predictive signs of difficult mask ventilation of difficult intubation (else than obesity)