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The purpose of the study is to determine the optimal method to withdraw non-invasive ventilation after an episode of hypercapnic respiratory failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Non-invasive ventilation is maintained during three nights after recovery of an episode of hypercapnic respiratory failure. |
|
| 2 | No Intervention | Discontinuation of NIV after the recovery of hypercapnic respiratory failure, without prolong it during night. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nocturnal non-invasive ventilation | Device | Prolongation of non-invasive ventilation during 3 nights. |
|
| Measure | Description | Time Frame |
|---|---|---|
| New episode of hypercapnic respiratory failure after discontinuation of non-invasive ventilation | At the end of enrollment time |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of long term dependency on non-invasive ventilation | At the end of enrollment time | |
| Hospital and 6-month survival | At the end of enrollment time |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jacobo Sellares, MD | Hospital Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital del Mar | Barcelona | Barcelona | 08003 | Spain | ||
| Hospital de Sant Pau |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28679605 | Derived | Sellares J, Ferrer M, Anton A, Loureiro H, Bencosme C, Alonso R, Martinez-Olondris P, Sayas J, Penacoba P, Torres A. Discontinuing noninvasive ventilation in severe chronic obstructive pulmonary disease exacerbations: a randomised controlled trial. Eur Respir J. 2017 Jul 5;50(1):1601448. doi: 10.1183/13993003.01448-2016. Print 2017 Jul. |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| Barcelona |
| Barcelona |
| 08025 |
| Spain |
| Hospital Clinic | Barcelona | Barcelona | 08036 | Spain |