Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Inclusion Criteria:

• written informed consent
• must be of legal age and competent
• Age > 18 years
• presently diagnosed with hypothyroidism

Exclusion Criteria:

• alcohol consumption >21 units per week
• Malignant disease
• pregnancy
• magnetic implants or material in the body
• BMI > 30
• Heart disease (NYHA >2)
• Uncontrolled hypertension
• Manifest diabetes mellitus
• Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.