Tolerability/PoP Study in Allergic Rhinitis After Intranasal Administration of AZD8848

A Double-blind, Placebo Controlled, Randomized, Parallel Group Study to Investigate the Tolerability, Safety, Pharmacodynamics and Pharmacokinetics of Repeated Weekly Doses of AZD8848 Administered Intranasally to Seasonal Allergic Rhinitis Patients

The primary purpose is to investigate tolerability/safety of repeated weekly doses of AZD8848 administered intranasally to seasonal allergic rhinitis patients.

Inclusion Criteria:

• Patients with a history of birch and/ or timothy grass pollen induced seasonal allergic rhinitis for at least the previous 2 years (verified by a positive skin prick test)
• Patients with need of treatment for their nasal symptoms during the pollen season

Exclusion Criteria:

• Clinical relevant disease or abnormality (past or present) - other than allergic rhinitis
• Symptomatic perennial allergic or non-allergic rhinitis
• A history of asthma