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| ID | Type | Description | Link |
|---|---|---|---|
| HIC #11312 |
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| Name | Class |
|---|---|
| Bristol-Myers Squibb | INDUSTRY |
| Astellas Pharma US, Inc. | INDUSTRY |
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Asymptomatic subjects with Type 2 Diabetes Mellitus were randomized to either screening with Tc-99m sestamibi adenosine SPECT imaging or no screening. All patients will be followed for 5 years for the occurrence of cardiac death or non-fatal myocardial infarction.
The aims are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Screening at start study with Adenosine vasodilator stress Tc-99m Sestamibi SPECT imaging | ||
| 2 | No screening |
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| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of silent myocardial ischemia in subjects randomized to screening was 22%. | At study entry | |
| At repeat stress imaging three years after recruitment 79% of subjects showed resolution of ischemia, whereas only 10% developed new ischemia. | 3 years after start | |
| Overall cardiac event rate (cardiac death, myocardial infarction) was 3.0%, not different in screened and not screened cohort | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Asymptomatic patients with type 2 diabetes mellitus
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| Name | Affiliation | Role |
|---|---|---|
| Frans J Wackers, MD | Yale University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale University School of Medicine | New Haven | Connecticut | 06520 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15277423 | Background | Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, Engel S, Ratner RE, Iskandrian AE; Detection of Ischemia in Asymptomatic Diabetics Investigators. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care. 2004 Aug;27(8):1954-61. doi: 10.2337/diacare.27.8.1954. | |
| 17682123 |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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blood
| Background |
| Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE; Detection of Ischemia in Asymptomatic Diabetics (DIAD) Investigators. Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study. Diabetes Care. 2007 Nov;30(11):2892-8. doi: 10.2337/dc07-1250. Epub 2007 Aug 6. |
| 19366774 | Derived | Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE; DIAD Investigators. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009 Apr 15;301(15):1547-55. doi: 10.1001/jama.2009.476. |
| D004700 | Endocrine System Diseases |