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| ID | Type | Description | Link |
|---|---|---|---|
| 2008-05 |
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We propose to study the intestinal secretion of ASCA by evaluating them in biopsy culture supernatants from a cohort of patients suffering from CD (n=80) and a cohort of control patients (UC (n=40) and patients without IBD (n=40 )).
Its diagnosis is based upon clinical, endoscopic and histological parameters but recent studies have shown that seric evaluation of immunological markers (anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic auti-antibodies (ANCA)) could be useful. Crohn's disease (CD) is an inflammatory bowel disease (IBD) of the young people. Antibodies anti-chitobisoside carbohydrate (ACCA), anti-laminaribioside carbohydrate (ALCA) and anti-mannobioside carbohydrate (AMCA) have been described as new serological markers of CD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Other | Patients with crohn disease |
|
| 2 | Other | Patients reached by hemorrhagic first side-colitis |
|
| 3 | Other | Patients controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling and biopsy | Other | Biopsy and blood : Research for various antibodies |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the performances of the dosage of the ASCA in floating it of culture of intestinal biopsies in that of their dosage in the serum | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Determine if the patients reached by disease of crohn not presenting ASCA in their serum represent one under group of disease of crohn | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sophie Desplat-Jego, MD | Assistance Publique des Hopitaux de Marseille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratoire d'Immunologie - Hopital de la Conception | Marseille | 13005 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24303014 | Result | Bertin D, Grimaud JC, Lesavre N, Benelmouloud C, Desjeux A, Garcia S, Desplat-Jego S. Targeting tissular immune response improves diagnostic performance of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease. PLoS One. 2013 Nov 26;8(11):e80433. doi: 10.1371/journal.pone.0080433. eCollection 2013. |
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| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D001706 | Biopsy |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Biopsy and blood sampling |
| Other |
Biopsy and blood : research for various antibodies |
|
| Biopsy and blood sampling | Other | Blood and biopsy : research for various antibodies |
|
| D007410 | Intestinal Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D003949 | Diagnostic Techniques, Surgical |