The purpose of this study is to determine multiple dose safety, tolerability and pharmacokinetics of ABT-333 under nonfasting conditions in healthy adult subjects, and to determine the effect of single dose administration of ketoconazole on steady state ABT-333 pharmacokinetics

Phase 1, Blinded, Randomized, Placebo-controlled Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-333

Inclusion Criteria:

• Main Selection Criteria for Healthy Volunteers:

  • Subject has provided written consent.
  • Subject is in general good health.

• If female, subject is postmenopausal for at least 2 years or surgically sterile.

• If female, subject is not pregnant and is not breast-feeding.

• Male or female between 18 and 55 years old, inclusive.

• If male, subject must be surgically sterile or practicing at least 1 method of birth control.

• Body Mass Index (BMI) is 18 to 29, inclusive.

Exclusion Criteria:

• See above for main selection criteria