Blood Samples to Evaluate Biomarkers of Donor Chimerism

Blood Samples to Evaluate Biomarkers of Donor Chimerism

We are interested in patient-specific factors that may affect the balance of recipient cells and donor cells in patients who receive stem cell transplants. We will look at the way the patient's body breaks down two drugs, fludarabine and mycophenolate mofetil, and how these two drugs affect the patient's body.

Inclusion Criteria:

• Diagnosed with a hematologic disease or malignancy
• Scheduled to receive nonablative conditioning with fludarabine and total body irradiation
• Donor is well-matched by high resolution DNA techniques.
• Scheduled to receive postgrafting immunosuppression of oral MMF (CellCept) and an oral calcineurin inhibitor.
• Age >18 years at the time of enrollment.

Exclusion criteria:

-Diagnosed with an immunodeficiency disorder