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| Name | Class |
|---|---|
| Pfizer | INDUSTRY |
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Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Dipyrone |
|
| 2 | Active Comparator | Ibuprofen |
|
| 3 | Active Comparator | Acetaminophen |
|
| 4 | Placebo Comparator | Parecoxib/Valdecoxib |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dipyrone | Drug | Dipyrone is given in the operation room with 2,5 g intravenously, followed by an oral regime of 4x1g on the ward |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of aggregation in platelet rich plasma fter 24 hours of treatment with analgetic doses | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of aggregation of platelet rich plasma 1hour and 4 hours after initiation of study drug | 4 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Matthias Schmauss, MD | research associate of the Ruhr University Bochum | Principal Investigator |
| Christoph Maier, Professor | Leader of the Department for Pain Medicine of the University Hospital Bergmannsheil Bochum | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BG University Hospital Bergmannsheil GmbH | Bochum | 44789 | Germany |
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| Ibuprofen | Drug | Ibuprofen is given orally 600mg in the Post Anesthesia Care Unit, followed by an oral regime of 800mg twice a day |
|
| Acetaminophen | Drug | Acetaminophen is given 1g intravenously in the Operation room, followed by an oral regime of 1g fourth a day |
|
| Acetaminophen | Drug | Acetaminophen is given 1g intravenously in the operation room, followed by 1g orally fourth a day |
|
| Parecoxib/Valdecoxib | Drug | 40mg Parecoxib are given intravenously in the operation room, followed by 40mg of Valdecoxib orally twice a day |
|
| Blood samples | Other | Blood samples for aggregometry are taken before induction of anesthesia, 1h after first drug intake, 4hs and 24hs after first intake |
|
| ID | Term |
|---|---|
| D004177 | Dipyrone |
| D007052 | Ibuprofen |
| D000082 | Acetaminophen |
| C409945 | parecoxib |
| C406224 | valdecoxib |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D000632 | Aminopyrine |
| D047069 | Pyrazolones |
| D011720 | Pyrazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010666 | Phenylpropionates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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