Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation

Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.

Inclusion Criteria:

• Planned traumatologic, orthopedic, visceral or plastic surgical procedures

Exclusion Criteria:

• Prior intake of drugs with effect on the platelet aggregation
• Patients with diseases of the gastrointestinal systems
• Patients with cardiac or circulatory diseases
• Patients receiving corticoids
• Patients with cold or asthma
• ASA-classification > 3