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The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Placebo Comparator | Patients were assigned to norepinephrine infused at the clinician's discretion. |
|
| 2 | Active Comparator | Patients were assigned to norepinephrine infused under computerized fuzzy logic control. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| norepinephrine infused at the clinician's discretion | Device |
| ||
| norepinephrine infused under computerized fuzzy logic control |
| Measure | Description | Time Frame |
|---|---|---|
| Time to shock resolution defined as cessation of vasopressor support |
| Measure | Description | Time Frame |
|---|---|---|
| 28 days survival, total amount of norepinephrine infused, duration of mechanical ventilation, and length of stay in the ICU |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Réanimation | Bobigny | Seine-Saint-Denis | 93000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19068113 | Derived | Merouani M, Guignard B, Vincent F, Borron SW, Karoubi P, Fosse JP, Cohen Y, Clec'h C, Vicaut E, Marbeuf-Gueye C, Lapostolle F, Adnet F. Norepinephrine weaning in septic shock patients by closed loop control based on fuzzy logic. Crit Care. 2008;12(6):R155. doi: 10.1186/cc7149. Epub 2008 Dec 9. |
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| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
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| Device |
|
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |