The objective is to develop a method to determine active ingredient uptake in oral care products.

Inclusion Criteria:

• Male or female volunteer 18 - 65 years of age (inclusive).
• Good general health with a minimum of twenty (20) natural, uncrowned teeth (excluding third molars)
• Able and willing to sign the informed consent form.
• Plaque score of at least 1.5 on the modified Quigley-Hein plaque index.
• No known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study

Exclusion Criteria:

• Medical condition which requires pre-medication prior to dental procedures/visits
• Medical condition which precludes not eating/drinking for 2 hours
• Advanced periodontal disease (gum disease)
• 5 or more decayed, untreated dental sites (cavities)
• Diseases of the soft or hard oral tissues
• Orthodontic appliances
• Abnormal salivary function
• Use of drugs that can affect salivary flow
• Use of antibiotics one (1) month prior to or during this study
• Use of any over the counter medications other than analgesics (i.e. aspirin, ibuprofen, acetaminophen, naproxyn, etc)
• Pregnant or breastfeeding.
• Participation in another clinical study in the month preceding this study
• Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy)

16 days