Effects of Intensive Lipid Lowering and Omega-3 Fatty Acid on Composition of Coronary Atherosclerotic Plaque

Effects of Intensive Lipid Lowering and Omega-3 Fatty Acid on Composition of Coronary Atherosclerotic Plaque: Serial Virtual Histology Intravascular Ultrasound Analysis

The purpose of this study is to determine whether intensive lipid lowering and Omega-3 fatty acid are effective in the treatment of coronary atherosclerotic plaque.

Inclusion Criteria:

• Acute coronary syndrome within 48 hours of symptom onset
• Have de novo non-culprit coronary artery stenosis 20% to 70% by visual estimation

Exclusion Criteria:

• Cardiogenic shock
• ST segment elevation myocardial infarction within 1 week
• Hematologic disorder: neutropenia (neutrophil<3000/mm3), thrombocytopenia (platelet<100,000/mm3)
• Liver enzyme elevation: serum aspartate aminotransferase or alanine aminotransferase concentrations more than 3 times the upper limit of normal
• Impaired renal function with serum creatinine > 2mg/dL
• Bleeding diathesis or history of coagulopathy
• Pregnancy
• Hypersensitivity to heparin, dye, aspirin, clopidogrel, statin, or fish