This trial is conducted in UK. The aim of this clinical trial is to investigate lowering the blood sugar and symptoms experienced during hypoglycaemia

Inclusion Criteria:

• Signed and dated informed consent obtained before any trial-related activities.
• Type 1 diabetes
• Treatment with insulin for minimum three months
• Duration of diabetes for more than 12 months
• Body Mass Index (BMI) less than 30 kg/m2
• HbA1c equal to or greater than 10 % based on analysis from central laboratory

Exclusion Criteria:

• Participation in any other clinical trial involving other investigational products within the last three months
• Current treatment with insulin in a daily dose above 100 U
• Episode of symptomatic hypoglycaemia, or a capillary plasma glucose value of less than 3.5 mmol/L in the past two weeks
• Hypoglycaemic unawareness or severe autonomic neuropathy
• Current treatment with drugs known to interfere with glucose metabolism such as systemic corticosteroids, non-selective beta-blockers and MAO inhibitors
• Current treatment with oral antidiabetic drugs
• Impaired hepatic function measured as ALAT of more than two times the upper reference limit
• Impaired renal function measured as creatinine of more than 150 micromol/L (1.7 mg/dL)
• Cardiac problems defined as decompensated heart failure (NYHA class III and IV) at any time and/or angina pectoris and/or myocardial infarction within the last 12 months
• Known or suspected allergy to trial product or related products
• Mental incapacity, unwillingness or language barriers precluding adequate understanding or co-operation
• Blood donation of more than 500 mL within the last three months
• Any condition that the Investigator and/or the Sponsor feels would interfere with study participation or evaluation of results
• Pregnancy or intention of becoming pregnant, breast-feeding or judged to be using inadequate contraceptive methods. Adequate contraceptive methods are sterilisation, intrauterine device (IUD), oral contraceptives or consistent use of barrier methods
• Previous participation in this trial