The Role of Endothelin in Pulmonary Hypertension

The Role of Endothelin in Pulmonary Hypertension

The purpose of the study is is to determine the effect, on the lung circulation, of BQ-123, an investigational compound which is not approved by the FDA.

Endothelin levels are increased in patients with pulmonary hypertension. We wish to compare the effect of an endothelin antagonist on pulmonary hypertension due to a variety of causes.

Inclusion Criteria:

• Healthy volunteers or known diagnosis of pulmonary hypertension

Exclusion Criteria:

• hypertension due to other reasons (not pulmonary)