A Multiple-Dose Study of MK-1006 (MK-1006-004)(TERMINATED)

A Multiple Dose Clinical Trial to Study the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-1006.

This study will asses the safety, tolerability, multiple-dose pharmacokinetics and pharmacodynamics of MK1006 in participants with type 2 diabetes.

Inclusion Criteria:

• Participant has a BMI less than or equal to 42 kg/m^2 at the screening visit
• Participant has been diagnosed with Type 2 Diabetes that is being treated either by diet and exercise alone or by single or combination oral anti-hyperglycemic medications
• Participant is willing to follow a diet containing approximately 50% carbohydrates, 20% protein, and 30% fat during the study
• Participant is a nonsmoker and has not used nicotine containing products for ~ 6 months before start of study

Exclusion Criteria:

• Participant must not be treated with three or more oral anti-hyperglycemic medications, insulin, or PPAR-gamma agonists
• Participant has a history of stroke, chronic seizures, or a major neurological disorder
• Participant has had an eye infection or other inflammatory eye condition within 2 weeks of first dose of study drug
• Participant has glaucoma or is blind
• Participant has a condition known to be related to cataract development
• Participant has had or will have incisional eye surgery within 6 months before screening or has had laser surgery (other than Lasik) within 3 months of screening
• Participant has a history of type 1 diabetes or ketoacidosis
• Participant cannot stop taking certain current medications during the study
• Participant consumes greater than 3 alcoholic beverages per day
• Participant consumes more than 6 servings of caffeinated beverages per day (1 serving is ~ 120 mg caffeine)
• Participant has a history of significant multiple or severe allergies or has had a reaction to or is intolerant of prescription/non-prescription drugs or food
• Participant uses recreational drugs or has had a history of drug abuse within 6 months of start of study