One Month Dose Response Study of AZD1981 in Asthma Patients Uncontrolled on Inhaled Steroids

A Double-blind, Randomised, Parallel Group, Multicentre Phase IIb, Placebo-Controlled, 1 Month Dose Response Study of AZD1981 in Asthma Patients Uncontrolled on Inhaled Steroids

The primary objective of this study is to evaluate efficacy of AZD1981 in uncontrolled asthmatic patients on maintenance inhaled glucocorticosteroids.

Inclusion Criteria:

• Six months history of asthma
• Daily use of inhaled glucocorticosteroids
• FEV1 40-85% of predicted normal
• Reversibility; increase in FEV1 more than 12% and 200 mL post-bronchodilator

Exclusion Criteria:

• Other clinically relevant disease or disorders
• History of smoking of more than 10 pack years
• Respiratory infection within 30 days