Clinical research study to determine anti-plaque efficacy of a prototype toothpastes for a 3 week brushing regiment.

Inclusion Criteria:

• Male or female volunteers at least 20 - 51 years of age
• Good general health
• Must sign informed consent form
• Minimum of 15 natural uncrowned teeth (excluding third molars) must be present
• No history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study

Exclusion Criteria:

• Subjects unable or unwilling to sign the informed consent form
• Medical condition which requires pre-medication prior to dental visits/procedures
• Moderate or advanced periodontal disease or heavy dental tartar (calculus)
• 5 or more decayed untreated dental sites at screening (cavities)
• Other disease of the hard or soft oral tissues.
• Impaired salivary function (e.g. Sjogren's syndrome or head and neck irradiation).
• Use of medications that are currently affecting salivary function
• Use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1
• Pregnant or nursing women
• Participation in any other clinical study within 1 week prior to enrollment into this study
• Use of tobacco products
• Subjects who must receive dental treatment during the study dates
• Current use of Antibiotics for any purpose
• Presence of an orthodontic appliance which interferes with plaque scoring
• History of allergy to common toothpaste ingredients
• History of allergy to arginine (amino acid)
• Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy)