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| Name | Class |
|---|---|
| AstraZeneca | INDUSTRY |
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The purpose of this study is to verify the existence of bacterial and/or fungal contamination during different technics of propofol with or without EDTA continuous infusion in patients undergoing general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | TCI with EDTA |
|
| 2 | Active Comparator | Re-filling of propofol syringe (Diprivan®-Astra Zeneca) with propofol containing EDTA |
|
| 3 | Active Comparator | Re-filling of propofol syringe (Diprivan®-Astra Zeneca) with propofol without EDTA |
|
| 4 | Active Comparator | Target controlled infusion of propofol without EDTA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EDTA without re-filling | Drug | Target controlled infusion of propofol containing EDTA (Diprivan®-Astra Zeneca) using equipment Diprifusor® (Astra Zeneca), without re-filling of syringe. |
| Measure | Description | Time Frame |
|---|---|---|
| Existence of bacterial and/or fungal contamination during different technics of propofol continuous infusion | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maria Jose C Carmona, Professor | Contact | 55-11-3069-5367 | maria.carmona@incor.usp.br | |
| Jose Otavio C Auler Jr, Full Professor | Contact | 55-11-3069-5232 | auler@hcnet.usp.br |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade de Sao Paulo Hospital das Clinicas | São Paulo | São Paulo | 05403-000 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16802492 | Background | Jansson JR, Fukada T, Ozaki M, Kimura S. Propofol EDTA and reduced incidence of infection. Anaesth Intensive Care. 2006 Jun;34(3):362-8. doi: 10.1177/0310057X0603400305. | |
| 17506735 | Background | Fukada T, Ozaki M. Microbial growth in propofol formulations with disodium edetate and the influence of venous access system dead space. Anaesthesia. 2007 Jun;62(6):575-80. doi: 10.1111/j.1365-2044.2007.05002.x. |
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| Propofol syringe re-filling with propofol containing EDTA | Other | Target controlled infusion of propofol (Diprivan®-Astra Zeneca) using equipment Diprifusor® (Astra Zeneca) with re-filling of syringe with propofol containing EDTA. |
|
| Target controlled infusion of propofol without EDTA | Other | Target controlled infusion of propofol without EDTA using Marshal´s technic with Alaris® or Fresenius® equipment |
|
| Re-filling of syringe with propofol without EDTA | Other | Target controlled infusion of propofol (Diprivan®-Astra Zeneca) using equipment Diprifusor® (Astra Zeneca) with re-filling of syringe with propofol not containing EDTA. |
|
| 12826541 | Background | Trepanier CA, Lessard MR. Propofol and the risk of transmission of infection. Can J Anaesth. 2003 Jun-Jul;50(6):533-7. doi: 10.1007/BF03018635. No abstract available. English, French. |
| 7791816 | Background | Bennett SN, McNeil MM, Bland LA, Arduino MJ, Villarino ME, Perrotta DM, Burwen DR, Welbel SF, Pegues DA, Stroud L, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med. 1995 Jul 20;333(3):147-54. doi: 10.1056/NEJM199507203330303. |
| ID | Term |
|---|---|
| D004492 | Edetic Acid |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D005029 | Ethylenediamines |
| D003959 | Diamines |
| D011073 | Polyamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
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