Pharmacogenetic Study of Methylphenidate in Attention Deficit/Hyperactivity Disorder(ADHD)

Association Between Norepinephrine Transporter Polymorphism and Response of Methylphenidate

The noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(ADHD).Methylphenidate also has been suspected as a inhibitor of norepinephrine transporter(SLC6A2). The investigators hypothesis is that norepinephrine transporter polymorphism is associated with responses and adverse effects of OROS-methylphenidate in treatment of ADHD.

Inclusion Criteria:

• ADHD
• Physically healthy

Exclusion Criteria:

• Neurological illness
• Concurrent additional psychiatric treatment
• < IQ 70
• Psychotic disorder
• Major mood disorder needed other psychiatric medication
• Significant suicidal ideation
• Pervasive developmental disorder