Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Low molecular weight heparin (LMWH) is injected in the dialysis circuit at the start of the session. In the present study we compare 3 different methods of injection of LMWH: parameters of dialysis efficiency and clotting are measured. The study lasts 3 sessions for each patient.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Injection of LMWH at the start of the hemodiafiltration session, at the inlet bloodline |
|
| 2 | Experimental | Injection of LMWH 5 minutes after the start of the hemodiafiltration session, at the inlet bloodline |
|
| 3 | Experimental | Injection of LMWH at the start of the hemodiafiltration session, at the outline bloodline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| At start of the session, at the inlet line | Procedure | Injection of LMWH at the inlet line, at the start of the hemodiafiltration session |
|
| Measure | Description | Time Frame |
|---|---|---|
| Anti-Xa activity at the end of the session | 240 min after start |
| Measure | Description | Time Frame |
|---|---|---|
| Anti-Xa activity during the session | at start, 30 min, 120 min and 180 min | |
| ETP during the session | at start, 30 min, 120 min, 180 min and 240 min | |
| Reduction ratio of urea |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Annemieke Dhondt, MD, PhD | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Ghent | Ghent | 9000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38189593 | Derived | Natale P, Palmer SC, Ruospo M, Longmuir H, Dodds B, Prasad R, Batt TJ, Jose MD, Strippoli GF. Anticoagulation for people receiving long-term haemodialysis. Cochrane Database Syst Rev. 2024 Jan 8;1(1):CD011858. doi: 10.1002/14651858.CD011858.pub2. | |
| 26076014 | Derived | Dhondt A, Pauwels R, Devreese K, Eloot S, Glorieux G, Vanholder R. Where and When To Inject Low Molecular Weight Heparin in Hemodiafiltration? A Cross Over Randomised Trial. PLoS One. 2015 Jun 15;10(6):e0128634. doi: 10.1371/journal.pone.0128634. eCollection 2015. |
| Label | URL |
|---|---|
| Website of the University Hospital Ghent | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 5 minutes after the start of the session, at the inlet line | Procedure | Injection of LMWH at the inlet line, 5 minutes after the start of the hemodiafiltration session |
|
| At the start of the session, at the outlet line | Procedure | Injection of LMWH at the outlet line, at the start of the hemodiafiltration session |
|
| after 10min, 180min and 240min |
| Reduction ratio of beta2microglobulin | after 10min, 180min and 240min |
| Visual inspection of membrane and circuit | After the hemodiafiltration session |
| pressure measurements along the circuit | inlet blood line, prefilter, transmembrane, outlet blood line | during the session |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |