Selective Digestive Decontamination in Carriers of Carbapenem-resistant Klebsiella Pneumoniae

A Randomized,Double-Blind,Placebo-Controled Trial of Selective Digestive Decontamination Using Oral Gentamicin and Oral Polymyxin E for Eradication of Carbapenem-Resistant Klebsiella Pneumoniae Carriage

There is an urgent need to control our current national outbreak of carbapenem-resistant Klebsiella pneumoniae (CRKP). The purpose of this study is to eradicate CRKP gastrointestinal carriage using selective digestive decontamination (SDD); with buccal and oral gentamicin and polymyxin E administration. This will reduce infections and hopefully mortality caused by CRKP.

Inclusion Criteria:

• Hospitalized men and women with a positive rectal swab for CRKP
• Age 18 years or older

Exclusion Criteria:

• Age less than 18 years
• Pregnant women, lactating women
• A known allergy to the study drugs