Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients

A Randomized, Double-blind, Placebo-controlled Ascending Dose Study to Evaluate the Effect of APL180 on Endothelial Function in Patients With Familial Hypercholesterolemia

This study will evaluate the effect of APL180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.

Inclusion Criteria:

• Confirmed presence of familial hypercholesterolemia
• Women must be sterilized or post-menopausal

Exclusion Criteria:

• Smoking an average of greater than 10 cigarettes per day
• History of cardiac events
• Very low or high body weight
• Treatment with fibrates or niacin
• High blood triglyceride levels

Other protocol-defined inclusion/exclusion criteria may apply.