Comparator Study of LT-NS001 in Healthy Subjects With Endoscopic Evaluation

A Double-Blind, Randomized, Active Comparator Study of LT-NS001 Versus Naprosyn for Seven Days in Healthy Subjects With Endoscopic Evaluation

The purpose of this study is to compare naproxen plasma levels and gastroduodenal mucosal injury after administration of LT-NS001 as compared to Naprosyn in subjects age 45-70.

Inclusion Criteria:

• BMI 18-30 kg/m2
• No NSAID's for 14 days prior to baseline endoscopy

Exclusion Criteria:

• Pregnant/Nursing women
• History of documented gastroduodenal ulcer