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| ID | Type | Description | Link |
|---|---|---|---|
| CICL670A US23T |
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| Name | Class |
|---|---|
| Novartis Pharmaceuticals | INDUSTRY |
A known risk of red blood cell transfusions is that it puts excess iron into the patient's body. Researchers are continually seeking the most effective method of measuring iron concentration. The purpose of this study is to determine how much iron has been deposited in a patient's heart and liver as a result of having received red blood cell transfusions using magnetic resonance imaging (MRI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Other | Patients who meet eligibility will be sent for radiographic imaging to include T2* cardiac and liver MRI to ascertain quantification of organ-specific iron concentrations as well as cardiac left ventricular ejection fraction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| T2* Cardiac and Liver MRI | Other | Patients will undergo an MRI of the heart and liver. |
|
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the incidence of clinically significant cardiac iron overload in heavily transfused MDS patients using T2* MRI. | A single T2* MRI will be performed on eligible patients. |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate left ventricular ejection fraction as assessed by T2* MRI. | A single T2* MRI will be performed on eligible patients. | |
| Evaluate liver iron concentration as assessed by R2* MRI | A single T2* MRI will be performed on eligible patients. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Feldman, M.D. | Weill Medical College of Cornell University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Weill Medical College of Cornell University | New York | New York | 10065 | United States |
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| ID | Term |
|---|---|
| D009190 | Myelodysplastic Syndromes |
| ID | Term |
|---|---|
| D001855 | Bone Marrow Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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